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Trade Name	Drug Name	Approved	Patent Expires	Indication
Copiktra	Duvelisib	2018-09-24	2029-2032	B-cell chronic lymphocytic leukemia , Follicular lymphoma
Farydak	Panobinostat	2015-02-23	2028	Multiple myeloma

Clinical Trials

Therapeutic Areas:

All

Classification:

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Approval:

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Status:

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Phases:

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Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

non-small-cell lung carcinoma

,

liver neoplasms

,

head and neck neoplasms

,

triple negative breast neoplasms

,

castration-resistant prostatic neoplasms

,

myeloproliferative disorders

,

leukemia myeloid chronic atypical bcr-abl negative

,

myelodysplastic-myeloproliferative diseases

,

myeloid leukemia accelerated phase

,

malignant mesothelioma

,

,

hepatocellular carcinoma

,

nasopharyngeal carcinoma

,

,

,

,

,

sickle cell anemia

,

beta-thalassemia

,

colonic neoplasms

,

rectal neoplasms

,

esophageal neoplasms

,

,

medulloblastoma

,

,

,

myeloid leukemia

,

breast neoplasms

,

non-hodgkin lymphoma

,

,

prostatic neoplasms

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

hematologic neoplasms

,

precursor cell lymphoblastic leukemia-lymphoma

,

,

,

,

large b-cell lymphoma diffuse

,

diffuse intrinsic pontine glioma

,

b-cell lymphoma

,

t-cell lymphoma cutaneous

,

b-cell chronic lymphocytic leukemia

,

t-cell leukemia

,

mantle-cell lymphoma

,

,

,

renal cell carcinoma

,

bcr-abl positive chronic myelogenous leukemia

,

myelomonocytic leukemia chronic

,

myeloid leukemia chronic-phase

,

neoplasm metastasis

,

,

lymphoid leukemia

,

extranodal nk-t-cell lymphoma

,

large-cell lymphoma anaplastic

,

immunoblastic lymphadenopathy

,

kidney neoplasms

,

waldenstrom macroglobulinemia

,

adult t-cell leukemia-lymphoma

,

,

brain neoplasms

,

small cell lung carcinoma

,

pancreatic neoplasms

,

,

,

myelomonocytic leukemia acute

,

myelomonocytic leukemia juvenile

,

,

,

sezary syndrome

,

lymphoproliferative disorders

,

b-cell lymphoma marginal zone

,

follicular lymphoma

,

mycosis fungoides

,

burkitt lymphoma

,

,

essential thrombocythemia

,

,

,

colorectal neoplasms

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

b-cell leukemia

,

enteropathy-associated t-cell lymphoma

,

plasma cell leukemia

,

biphenotypic leukemia acute

,

,

stomach neoplasms

,

,

thyroid neoplasms

,

thyroid diseases

,

neuroendocrine tumors

,

thrombocytopenia

,

interdigitating dendritic cell sarcoma

,

,

phenylketonurias

,

,

multiple myeloma

,

,

plasma cell neoplasms

,

myelodysplastic syndromes

,

hodgkin disease

,

,

myeloid leukemia acute

,

primary myelofibrosis

,

graft vs host disease

,

polycythemia vera

,

bronchiolitis obliterans syndrome

,

healthy volunteers/patients

,

b-cell lymphoma

,

large b-cell lymphoma diffuse

,

extranodal nk-t-cell lymphoma

,

adult t-cell leukemia-lymphoma

,

t-cell leukemia

,

sezary syndrome

,

mycosis fungoides

,

,

,

hepatic insufficiency

,

multiple myeloma

,

hodgkin disease

,

plasma cell neoplasms

,

large-cell lymphoma anaplastic

,

t-cell lymphoma

,

,

hematologic neoplasms

,

reactive arthritis

,

enteropathy-associated t-cell lymphoma

,

head and neck neoplasms

,

squamous cell carcinoma of head and neck

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

prolymphocytic leukemia t-cell

,

large granular lymphocytic leukemia

,

rheumatoid arthritis

,

,

coronavirus infections

,

,

,

prolymphocytic leukemia

,

t-cell lymphoma cutaneous

,

,

b-cell chronic lymphocytic leukemia

,

non-hodgkin lymphoma

,

follicular lymphoma

,

t-cell lymphoma peripheral

,

,

lymphoid leukemia

,

b-cell lymphoma marginal zone

,

,

immunoblastic lymphadenopathy

,

hereditary sensory and autonomic neuropathies

ovarian neoplasms

,

kidney neoplasms

,

,

myelodysplastic syndromes

,

myeloid leukemia acute

,

hematologic diseases

,

myelomonocytic leukemia chronic

,

myeloid leukemia

,

myelomonocytic leukemia juvenile

,

,

bone marrow diseases

,

,

gastrointestinal stromal tumors

,

,

multiple myeloma

,

plasma cell neoplasms

,

alveolar soft part sarcoma

,

,

head and neck neoplasms

,

colonic neoplasms

,

rectal neoplasms

,

,

intestinal neoplasms

,

thymus neoplasms

,

,

non-small-cell lung carcinoma

,

colorectal neoplasms

,

triple negative breast neoplasms

,

,

hepatocellular carcinoma

,

renal cell carcinoma

,

,

liver neoplasms

,

,

breast neoplasms

,

ovarian epithelial carcinoma

,

,

squamous cell carcinoma of head and neck

,

,

small cell lung carcinoma

,

,

squamous cell neoplasms

,

,

pancreatic ductal carcinoma

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

pancreatic neoplasms

,

esophageal neoplasms

,

squamous cell carcinoma

,

esophageal squamous cell carcinoma

,

clear cell adenocarcinoma

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

prostatic neoplasms

,

castration-resistant prostatic neoplasms

,

neuroendocrine tumors

,

urologic neoplasms

,

thyroid neoplasms

,

uterine cervical neoplasms

,

cholangiocarcinoma

,

unknown primary neoplasms

,

adenocarcinoma of lung

,

,

uveal neoplasms

,

adenomyoepithelioma

,

,

neoplasm metastasis

,

hematologic neoplasms

,

anaplastic thyroid carcinoma

,

malignant mesothelioma

,

neuroendocrine carcinoma

,

,

brain neoplasms

,

,

,

diffuse intrinsic pontine glioma

,

precursor cell lymphoblastic leukemia-lymphoma

,

lymphoid leukemia

healthy volunteers/patients

,

,

bcr-abl positive chronic myelogenous leukemia

,

type 2 diabetes mellitus

,

glandular and epithelial neoplasms

,

,

gata2 deficiency

,

central nervous system neoplasms

,

,

fallopian tube diseases

,

neurologic manifestations

,

,

interdigitating dendritic cell sarcoma

,

myeloproliferative disorders

,

neoplasms by histologic type

,

adenosquamous carcinoma

,

chronic hepatitis c

,

,

venous thromboembolism

,

thromboembolism

,

pharmacokinetics

,

,

behcet syndrome

,

aids-related complex

,

pleural effusion

,

respiratory tract neoplasms

,

bronchogenic carcinoma

,

thoracic neoplasms

,

malignant pleural effusion

,

pleural diseases

,

pleural neoplasms

,

immunosuppression therapy

,

small cell lung carcinoma

,

transitional cell carcinoma

,

ovarian neoplasms

,

non-hodgkin lymphoma

,

triple negative breast neoplasms

,

urologic neoplasms

,

squamous cell carcinoma

,

,

biliary tract neoplasms

,

malignant mesothelioma

,

large b-cell lymphoma diffuse

,

,

uterine cervical neoplasms

,

neoplasms by site

,

castration-resistant prostatic neoplasms

,

b-cell lymphoma

,

endometrial neoplasms

,

,

squamous cell neoplasms

,

,

uveal neoplasms

,

,

hematologic neoplasms

,

t-cell lymphoma peripheral

,

t-cell lymphoma

,

b-cell chronic lymphocytic leukemia

,

,

neuroendocrine tumors

,

gastrointestinal neoplasms

,

adenocarcinoma of lung

,

myeloid leukemia acute

,

cholangiocarcinoma

,

graft vs host disease

,

interstitial lung diseases

,

follicular lymphoma

,

merkel cell carcinoma

,

peritoneal neoplasms

,

spinocerebellar degenerations

,

,

graft rejection

,

psychology rejection

,

clear cell adenocarcinoma

,

,

,

medulloblastoma

,

,

,

rhabdomyosarcoma

,

diffuse intrinsic pontine glioma

,

,

autoimmune diseases

,

multiple sclerosis

,

waldenstrom macroglobulinemia

,

extranodal nk-t-cell lymphoma

,

precursor cell lymphoblastic leukemia-lymphoma

,

burkitt lymphoma

,

female genital neoplasms

,

endometrioid carcinoma

,

,

,

urogenital neoplasms

,

organ transplantation

,

neuroendocrine carcinoma

,

urinary bladder diseases

,

microsatellite instability

,

basal cell carcinoma

,

basal cell neoplasms

,

diffuse scleroderma

,

laryngeal diseases

,

,

heart transplantation

,

,

male breast neoplasms

,

b-cell leukemia

,

tertiary lymphoid structures

,

oropharyngeal neoplasms

,

,

prostatic diseases

,

non-muscle invasive bladder neoplasms

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

diabetic neuropathies

,

nephrotic syndrome

,

focal segmental glomerulosclerosis

,

lipoid nephrosis

,

bronchiolitis obliterans syndrome

,

diabetic nephropathies

,

kidney diseases

,

common variable immunodeficiency

,

large-cell lymphoma anaplastic

,

,

phenylketonurias

,

bile duct neoplasms

,

serous cystadenocarcinoma

,

papillary thyroid cancer

,

,

salivary gland neoplasms

,

genetic therapy

,

smoldering multiple myeloma

,

uterine neoplasms

,

large cell carcinoma

,

endometrial stromal tumors

,

small cell carcinoma

,

penile neoplasms

,

adrenocortical carcinoma

,

digestive system diseases

,

,

,

,

,

invasive hydatidiform mole

,

,

,

,

bronchiolo-alveolar adenocarcinoma

,

drug-related side effects and adverse reactions

,

carcinoid tumor

,

hypersensitivity

,

thyroid neoplasms

,

precancerous conditions

,

bronchopulmonary dysplasia

,

tobacco smoking

,

b-cell lymphoma marginal zone

,

mantle-cell lymphoma

,

meningeal carcinomatosis

,

systemic scleroderma

,

patient preference

,

,

oral leukoplakia

,

churg-strauss syndrome

,

microscopic polyangiitis

,

oligodendroglioma

,

myeloid leukemia

,

,

,

ankylosing spondylitis

,

,

inflammatory breast neoplasms

,

immunoglobulin g4-related disease

,

,

,

progressive multifocal leukoencephalopathy

,

gastrointestinal stromal tumors

,

male urogenital diseases

,

female urogenital diseases

,

female urogenital diseases and pregnancy complications

,

urogenital diseases

,

reactive arthritis

,

hereditary nonpolyposis colorectal neoplasms

,

,

aplastic anemia

,

,

,

non-small-cell lung carcinoma

,

colorectal neoplasms

,

neoplasm metastasis

,

squamous cell carcinoma of head and neck

,

prostatic neoplasms

,

head and neck neoplasms

,

breast neoplasms

,

pancreatic neoplasms

,

liver neoplasms

,

hepatocellular carcinoma

,

urinary bladder neoplasms

,

,

brain neoplasms

,

stomach neoplasms

,

hodgkin disease

,

multiple myeloma

,

,

colonic neoplasms

,

,

rectal neoplasms

,

esophageal neoplasms

,

,

,

,

cutaneous malignant melanoma

,

pancreatic ductal carcinoma

,

fallopian tube neoplasms

,

systemic lupus erythematosus

,

myelodysplastic syndromes

,

plasma cell neoplasms

,

,

ovarian epithelial carcinoma

,

,

,

esophageal squamous cell carcinoma

,

ulcerative colitis

,

juvenile arthritis

,

psoriatic arthritis

,

sjogren's syndrome

,

,

,

lupus nephritis

,

giant cell arteritis

,

respiratory tract diseases

,

granulomatosis with polyangiitis

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

hyperlipidemias

,

polymyalgia rheumatica

,

vascular diseases

,

,

systemic vasculitis

,

disease progression

,

pathologic complete response

,

,

rheumatoid arthritis

,

renal cell carcinoma

,

,

,

kidney transplantation

,

acquired immunodeficiency syndrome

,

,

kidney neoplasms

,

delayed graft function

,

chronic kidney failure

,

coronary artery disease

,

,

hiv-associated lipodystrophy syndrome

,

epstein-barr virus infections

,

,

transplantation

,

mitochondrial diseases

,

,

,

parkinson disease

,

,

cardiomyopathies

,

dilated cardiomyopathy

,

,

,

alzheimer disease

,

progressive supranuclear palsy

,

,

,

diabetes mellitus

Globulin, immune

,

multiple myeloma

,

colorectal neoplasms

,

pancreatic neoplasms

,

,

endometrial neoplasms

,

endometrioid carcinoma

,

acinar cell carcinoma

,

fallopian tube neoplasms

,

ovarian epithelial carcinoma

,

ovarian neoplasms

,

peritoneal neoplasms

colorectal neoplasms

,

esophageal squamous cell carcinoma

,

anaplastic thyroid carcinoma

,

disease progression

,

hematologic neoplasms

,

,

castration-resistant prostatic neoplasms

,

pancreatic neoplasms

,

pancreatic ductal carcinoma

,

head and neck neoplasms

,

squamous cell carcinoma

,

,

renal cell carcinoma

,

stomach neoplasms

,

urologic neoplasms

,

transitional cell carcinoma

,

,

,

squamous cell carcinoma of head and neck

,

invasive hydatidiform mole

,

,

urinary bladder neoplasms

,

hemangiosarcoma

,

squamous cell neoplasms

,

endometrial neoplasms

,

non-hodgkin lymphoma

,

,

immune system diseases

,

t-cell lymphoma

,

lymphoproliferative disorders

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

malignant mesothelioma

,

neoplasms by histologic type

,

neoplasms by site

,

lymphatic diseases

,

immunoproliferative disorders

,

breast neoplasms

,

prostatic neoplasms

,

non-small-cell lung carcinoma

,

neoplasm metastasis

,

ovarian neoplasms

,

,

triple negative breast neoplasms

,

adenocarcinoma of lung

,

brain neoplasms

,

osteitis deformans

,

hereditary sensory and autonomic neuropathies

,

fallopian tube neoplasms

,

peritoneal neoplasms

,

lobular carcinoma

,

ductal carcinoma breast

,

,

neuroendocrine tumors

,

large cell carcinoma

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